| abstract |
An antibody is provided that specifically binds to glycosylated PD-L1 relative to non-glycosylated PD-L1, blocks binding of PD-L1 to PD-1, and promotes internalization and degradation of PD-L1 . There is an antibody that recognizes a specific epitope on the glycosylated PD-L1 protein, blocks binding of PD-L1 to PD-1, and enables dualization of PD-L1 on the cell do. In some embodiments, a PD-L1 polypeptide is provided that comprises an amino acid residue glycosylated at the amino and carboxy terminus of the PD-L1 extracellular domain. Methods of using the antibodies for the treatment of cancer, particularly PD-L1 positive cancers, are also provided. |