| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3c2e77f8dfda692ca527454d23ecc03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fa13ec9da60f0600c377d6bd2955dd2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-15 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61D19-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4746
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61D19-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-00 |
| filingDate |
2016-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2052d5b5b94082b3b3e7b88a2b14241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70e85d5acaa0591e68ddfb8fc92a8ae0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96fe3451945d2cb78c1454376db7eb78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fd5d8446eee39b8baa826bc8c8e0d79 |
| publicationDate |
2018-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20180128386-A |
| titleOfInvention |
Manipulation of humanized kidney by genetic complementarity |
| abstract |
Human or humanized tissues and organs suitable for transplantation are disclosed herein. Genetic editing of the host animal provides a niche for complementing missing gene information by donor stem cells. In order to knock out or weaken the gene responsible for the growth and / or differentiation of the target organ, the host genome is edited and injected with the donor stem cells into the animal at the embryonic stage to remove the missing genetic information . The result is a chimeric animal in which the complemented tissue (human / humanized organ) matches the donor's genotype and phenotype. Such organs can be made into a single generation and the stem cells can be harvested or produced from the patient ' s body. As described herein, multiple genes can be simultaneously edited in a cell or embryo to produce a " gap " for the complemented tissue. A number of genes can be targeted for editing using nuclease targeted and homologous target recovery (HDR) templates in vertebrate cells or embryos. |
| priorityDate |
2015-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |