| abstract |
The present invention relates to a pharmaceutical composition for the prevention, treatment or cognitive improvement of dementia comprising an acanthoside B compound as an active ingredient. In the present invention, acanthoside B, an acetylcholine esterase-inhibiting active ingredient isolated from desalted tobacco smoke extract and extract, is excellent in cranial nerve cell protection activity through inhibition of cranial nerve inflammation, and scopolamine-induced memory decay animal model The passive avoidance test and the Y-maze test significantly improved memory and spatial cognitive abilities. The acanthocide B or extract of the present invention of the present invention can be applied to a pharmaceutical composition for preventing or treating dementia, a cognitive function improving pharmaceutical composition or a health functional food or feed for improving memory and cognitive function. |