abstract |
Recombinant a-glucosidase is expressed in Chinese hamster ovary (CHO) cells and contains one or two mannose-6-phosphate residues compared to the content of N-glycan units retaining one or two mannose- Or recombinant acid? -Glucosidase comprising an increased content of N-glycan units having two mannose-6-phosphate residues; At least one buffer selected from the group consisting of citrate, phosphate and combinations thereof; And at least one excipient selected from the group consisting of mannitol, polysorbate 80, and combinations thereof, wherein the formulation has a pH of from about 5.0 to about pH 7.0. Also provided are methods of treating Pompe disease using these pharmaceutical formulations. |