| abstract |
The present invention is directed to a method of treating or preventing diabetes mellitus comprising administering to a patient a therapeutically effective amount of at least one compound selected from the group consisting of chemotherapy-induced diarrhea, diabetes mellitus, Type II diabetes, gestational diabetes mellitus, fasting glucose deficiency, glucose tolerance deficiency, insulin resistance, hyperglycemia, Systemic TGR5 agonists useful in the treatment of disorders associated with parenteral nutrition during premenstrual syndrome, and IBS, and other TGR5 related diseases and disorders. (I ') Wherein R 1 , R 2 , R 2 ' , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , Q and n are as described herein. |