| abstract |
More particularly, the present invention relates to a novel probe capable of monitoring autophagy by specifically detecting LC3A, LC3C, GABARAP, GABARAPL1 or GABARAPL2 of an autologous animal from living cells, and a probe . Probe for detecting self-phagocytic vesicles of the present invention LC3- interaction motif ATG13 (LIR) and a portion ApPDE4 (Aplysia phosphodiesterase 4), and the LIR can specifically detect LC3A, LC3C, GABARAP, GABARAPL1, and GABARAPL2 of autologous phagocytes, and HyD can enhance the binding ability of the autologous phagocytes with the membrane Therefore, it can be easily used for detecting the self-contained body. |