abstract |
This disclosure provides codon-optimized Factor VIII sequences, vectors and host cells containing codon-optimized Factor VIII sequences, polypeptides encoded by codon-optimized Factor VIII sequences, and methods of making such polypeptides. The disclosure also provides a method of treating a hemorrhagic disorder, such as hemophilia, comprising administering to the subject a codon-optimized Factor VIII factor nucleic acid sequence or a polypeptide encoded thereby. |