| abstract |
The present invention relates to a binding molecule capable of specifically binding to Lrig-1 protein, which is a protein existing on the surface of regulatory T cells. The binding molecule provided by the present invention activates the function of regulatory T cells and is induced by overexpressed activation and expression of various immune cells and inflammatory cells. For example, autoimmune diseases, graft versus host disease, Related diseases such as organ transplant rejection, asthma, atopy, or acute or chronic inflammatory diseases can be effectively prevented, ameliorated or treated. In addition, the binding molecule specific to the Lrig-1 protein according to the present invention, preferably the antibody, can be more effectively targeted to the Lrig-1 protein as compared with the commercially available antibody against Lrig-1, There is also a very good advantage. |