| abstract |
The present invention relates to a pharmaceutical composition for cognition and memory enhancement containing a Cudrania tricuspidata fruit extract, and a health functional food containing it as an active ingredient. The pharmaceutical composition of the present invention reduces the activity of the neurotransmitter, acetylcholinesterase, increases the activity of ERK and CREB, which are cognitive and memory-related proteins, increases the acetylcholine content, which is a neurotransmitter in the blood, The expression and activity of the related proteins AMPK, CREB and SIRT3 are increased, and the expression of neurogenesis and neuronal cell differentiation related genome can improve the recognition and memory ability. |