| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c9372268648c892d31ec77eaa17ab55 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2059
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2018 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 |
| filingDate |
2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f542100508b65b6bac40604d0c2f64a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6540466f479541e8b33f541ea1de957 |
| publicationDate |
2018-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20180112048-A |
| titleOfInvention |
Oral formulation of clomiphene isomers and methods of using them for the treatment of hypogonadism |
| abstract |
The present invention is a pharmaceutical oral dosage form comprising (A) both clomiphene or a pharmaceutically acceptable salt thereof and (B) cis-clomiphene or a pharmaceutically acceptable salt thereof, wherein ( i) the ratio of (A) to (B) in the formulation is about 70:30; (ii) the amount of (A) in the formulation is about 12.5 mg or about 25 mg; And (iii) the amount of (B) in the formulation is 15 mg or less. Such pharmaceutical dosage forms are useful in treating secondary gonadal hypogonality in men and in minimizing side effects of certain antiestrogen drugs such as cognitive impairment, facial flushing and bone loss, osteoporosis, and skeletal fractures. |
| priorityDate |
2016-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |