| abstract |
The present invention relates to an insulin conjugate in which insulin, a non-peptidic polymer and an immunoglobulin Fc region are covalently linked to each other to improve persistence and stability in vivo, a persistent preparation containing the same, and a preparation method thereof. The insulin conjugate of the present invention maintains a relatively high in vivo activity of the peptide and significantly increases the half-life of the blood, thereby greatly improving the adherence and compliance of the insulin with the insulin. |