| abstract |
There is provided a compound having the structure of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or said pharmaceutically acceptable salt: Wherein A, A 'and A "are independently O, C = O, CR' or NR", wherein R 'and R "are independently H, amino, -NR 7 COR 6 , COR 6 , -CONR 7 R 8, C 1 -C 6 alkyl, or hydroxy (C 1 -C 6 alkyl) may be, R "is present, or is present in the case of can members, allows the law of atoms a, a ' And A " is O or C = O; R 0 and R are independently H, Br, Cl, F or C 1 -C 6 alkyl; R 1 is H, C 1 -C 6 alkyl , or hydroxy (C 1 -C 6 alkyl); R 2 is H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxy (C 1 -C 6 alkyl), phenyl (C 1 -C from (CH 2) n -W group consisting of - 6 alkyl), formyl, heteroaryl, heterocyclic, -COR 6, -OCOR 6, -COOR 6, -NR 7 COR 6, -CONR 7 R 8, and selected, and wherein W is cyano, hydroxy, C 3 -C 8 cycloalkyl, -SO 2 NR 7 and R 8, or -SO 2 -R 9, R 9 is C 1 -C 6 alkyl, C 3 - C 8 cycloalkyl, heteroaryl, Is heterocyclic, wherein alkyl, cycloalkyl, heterocyclic, or heteroaryl each of which unsubstituted or substituted by halo, cyano, hydroxy, or C 1 -C 6 alkyl may be substituted with, and; X is CR 3, or N, wherein R 3 can be H or C 1 -C 6 alkyl; R 4 and R 5 are independently H, amino, C 1 -C 6 alkyl, or hydroxy (C 1 -C 6 alkyl) R 6 , R 7 and R 8 are each independently H, C 1 -C 6 alkyl, C 1 -C 4 alkoxy (C 1 -C 6 alkyl), or C 3 -C 8 cycloalkyl, C 1 -C 6 alkyl is optionally substituted with halo, CN or hydroxy; or R 7 and R 8 , together with the atoms bonded thereto, form a 5-or 6-membered ring, Halo, hydroxy, CN, or C 1 -C 6 alkyl; n is 0, 1, 2 or 3; Also provided are methods of treatment as Janus kinase inhibitors, and pharmaceutical compositions containing compounds of the invention or other therapeutic agents and combinations thereof. |