| abstract |
The present invention provides for the synthesis of a compound according to formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, a pharmaceutically acceptable preparation and use. For compounds of formula (I), X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b and R 5 are as defined in the specification. The compounds of formula (I) of the present invention are inhibitors of eIF4A and find utility in any number of therapeutic applications including, but not limited to, inflammation and treatment of various cancers. |