| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17a65bc83ed569f525294332fa4787fc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-10002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-04011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-22 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-686
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-686 |
| filingDate |
2013-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8881066056483d1bd43bedfda4021f29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8878b17d132047b83bfc25efe6fcb143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60d5fa20bffc7cfec35fd3b962e44861 |
| publicationDate |
2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20180088926-A |
| titleOfInvention |
Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| abstract |
Mutations that confer resistance to treatment with BTK inhibitors are described herein. Modified BTK polypeptides that exhibit reduced inhibition (i.e., resistance) to covalent and / or irreversible BTK inhibitors are described herein. Modifications of PLCĪ³2 and CARD11 polypeptides that confer resistance to treatment with BTK inhibitors are also described herein. Modified polypeptides and diagnostic methods for detecting nucleic acids encoding the altered polypeptides and methods of application thereof are also described herein. Compositions, combinations and kits containing modified polypeptides, and methods of using the altered polypeptides are described herein. Methods of using modified BTK polypeptides as screening agents for identification and design of second generation BTK inhibitors are also described herein. |
| priorityDate |
2012-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |