abstract |
(5-azacytidine or 2'-deoxy-5-azacytidine), which is clinically used as a bone marrow tumor therapeutic drug, has high stability against metabolic enzyme cytidine deaminase, (Inhibits) protein synthesis by being absorbed and permeating into the biosynthetic pathway of RNA and DNA. A novel compound represented by the formula (1): wherein R is a hydroxyl group or a hydrogen atom, and R 1 and R 2 are each a substituted or unsubstituted benzyl group. |