| abstract |
A compound having the action of regulating the activity of the androgen receptor, represented by the following formula, or a pharmaceutically acceptable salt thereof: The X is S, O, Z is (R a) n -A- (CR 13 R 14) 0-1 - (CR 11 R 12) 0-1 - a, A is an aryl, a heteroaryl, R 1 is Alkyl, cycloalkyl, cycloalkyl, alkenyl, alkynyl, alkoxyalkyl, aryl, arylalkyl, heterocyclic, heterocyclic alkyl, R 2 is hydrogen, halogen, alkyl, cycloalkyl, phenyl, R 3 is hydrogen, halogen Alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, cycloalkenyl, aryl, arylalkyl, heterocyclic, heterocyclic alkyl, acyl, cycloalkylcarbonyl, benzoyl, spiroalkyl, adamantyl, silyl, R 31 R 32 NCO- and R 4 and R 5 represent hydrogen, halogen, alkyl, phenyl, cycloalkyl. |