| abstract |
The present invention relates to a plasminogen replenishment method in a plasminogen-deficient subject, and a method of treating plasminogen-deficiency in a plasminogen-deficient subject. These methods increase the plasminogen activity level of a plasminogen-deficient subject by at least about 1%, more particularly by about 10% or more, of normal plasminogen activity, and by increasing the plasminogen Comprising administering to the plasminogen-deficient subject a dose of plasminogen, more particularly Glu-plasminogen, in order to maintain an active level. The subject of plasminogen-deficiency of the present invention may be suffering from Type 1, Type 2 plasminogen-deficiency or acquired deficiency. |