| abstract |
In some aspects, the invention provides an antibody comprising: an antibody; Linker; And an antibody-drug conjugate comprising at least two active agents. In a preferred embodiment, the linker comprises a peptide sequence of a plurality of amino acids, and at least two active agents are covalently linked to the side chains of the amino acid. The antibody-drug conjugate may comprise a self-immolative group, preferably two self-sacrificial groups. The linker may comprise, for example, an O-substituted oxime wherein the oxygen atom of the oxime is replaced by a group linking the oxime and the activator via a covalent bond; The carbon atom of the oxime is replaced by a group linking the oxime and the antibody via a covalent bond. |