| abstract |
The present invention relates to a plasmid-based Vibriol cholera CTX phage cloning system, which comprises cloning a CTX phage genomic sequence into a plasmid capable of replicating the plasmid, amplifying it in a host cell, and introducing it into a V. cholera strain, Can be reproduced. Also, the plasmid of the present invention can be used to produce a strain having a plurality of CTX phages in a single Vibrio cholera host cell. |