abstract |
The present invention provides for the synthesis of a compound according to formula (I), or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, pharmaceutically acceptable preparations and uses. For a compound of formula I, A 1, A 2, A 3, A 4, A 5, A 6, A 7, W 1, R 1, R 2, R 3, R 4, R 5a, R 5b, R 6, R 7, R 7a, R 7b, R 8, R 8a, R 8b, R 9, R 9a, R 9b , and R 10 and the subscripts "m" and "n" are as defined in the specification. The compounds of formula I of the present invention are inhibitors of Mnk and have utility in any number of therapeutic applications including, but not limited to, inflammation and the treatment of various cancers. |