| abstract |
The present invention provides for the synthesis of a compound according to formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, a pharmaceutically acceptable preparation and use. For a compound of formula I, A 1, A 2, A 3, A 4, A 5, W 1, Y, R 1, R 2, R 3, R 4, R 5, R 6a, R 6b, R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and the subscript "n" are as defined in the specification. The compounds of formula I of the present invention are inhibitors of Mnk and have utility in any number of therapeutic applications including, but not limited to, inflammation and the treatment of various cancers. |