http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180069323-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55a854abe5a37b075d9a25a1cfcb46eb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-324 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-718 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-708 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-708 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-718 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-105 |
| filingDate | 2016-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39ff968f85098ad39c41f9e31c75eaa1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2076ab010b311c87d3c2d52b1c037f6 |
| publicationDate | 2018-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20180069323-A |
| titleOfInvention | The compositions for prevention or treatment of autoimmune diseases |
| abstract | The present invention relates to a pharmaceutical composition and a health functional food for preventing and treating a neurological autoimmune disease which contains a mixed extract of Coptidis rhizome , Scutellariae radix and Rhei Rhizoma as an active ingredient, , The mixed extract of the present invention not only improves the degree of neurological impairment and weight loss of disease in an experimental autoimmune encephalomyelitis (EAE) animal model, but also reduces dehydration and neurosarcoma (microglia and astrocytes) in the spinal cord (ICAM-1, VCAM-1), the expression of inflammatory cytokines (TNF-α, IL-1ß), chemokines (RANTES, MCP-1 and MIP- (Claudin-3, claudin-5, ZO-1) and the NF-kB signaling pathway. These effects were related to the mechanism by which the Treg cell activity was increased and Th1 cell halation was inhibited. Therefore, the mixed extract of the present invention can be used as a medicament which can prevent or treat the development of autoimmune diseases including neurological diseases including multiple sclerosis. |
| priorityDate | 2016-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 763.