| abstract |
The present invention provides compositions and methods useful in the treatment of diseases treatable with therapies through the introduction of multigene expression vectors. More specifically, the invention provides a vector and a polynucleotide encoding a polypeptide for the treatment of heart disease, wherein the polypeptide may comprise a cytokine, a chemokine, and / or an angiogenic polypeptide, or a functional variant thereof. Also provided as a composition of the present invention are useful linkers for linking and expressing functional (biologically active) polypeptides from single, multigene-expressing constructs. |