abstract |
The present invention relates to a method for producing a physiologically active polypeptide and an immunoglobulin Fc conjugate having a weakened immune response and a conjugate related thereto, a composition for reducing the immune response comprising the conjugate, and a method for reducing the immune response of the physiologically active polypeptide. Further, the present invention relates to a method for maintaining the binding strength of the binding body with the Fc gamma receptor and / or complement and a composition comprising the binding agent. |