| abstract |
In the present invention, the major antigenic epitopes in the VP1 protein of foot-and-mouth disease viruses with different serotypes are codon-optimized, and then the fusion protein antigen (Multi-VP1 epitopes) is converted into a soluble protein The present invention relates to a vector capable of expressing or purifying an Escherichia coli, a vector transformed thereby, a soluble Multi-VP1 epitope protein expressed and purified from the microorganism, and a vaccine for the protein. More particularly, An Escherichia coli expression vector containing an O, A, Asia1 type foot-and-mouth disease virus or a gene linking major antigen epitopes in the VP1 protein of different local foot-and-mouth disease viruses in the same serotype, a specific recombinant Escherichia coli And a soluble Multi-VP1 epit < RTI ID = 0.0 > epitope < / RTI & ope protein as an active ingredient. |