| abstract |
The present invention relates to the field of medicinal chemistry. In particular, the present invention relates to a class of alkynylpyridine prolyl hydroxylase inhibitors (I). The present experiments demonstrate that these compounds have excellent pyrrolyl hydroxylase inhibiting activity and can promote the production and secretion of erythropoietin in cell or animal models and thus can promote the production of red blood cells, , And for the treatment or prevention of ischemic diseases such as ischemic stroke, myocardial ischemia and other related diseases. The present invention also discloses methods for preparing such compounds. Formula I In this formula, X, Y, L, n and R 1 to R 5 are as defined herein. |