abstract |
The present application is directed to a recombinant viral vector or plasmid vector comprising a) a DNA sequence encoding a transforming growth factor superfamily or neurotrophic factor protein operably linked to a promoter, Producing; b) transfecting said recombinant vector into a population of cultured cells to form a population of cultured cells; And c) transplanting said transfected cell clusters into a peripheral region of the injured nerve, wherein said DNA sequence is expressed in the peripheral region of said damaged nerve, thereby preventing neurodegeneration. |