| abstract |
A pharmaceutical composition comprising a 3-aminoisoxazolopyridine compound of the formula (I) having IDO1 and / or TDO inhibitory activity is described: Wherein W is CR, N or N-oxide; X is CR2, N or N-oxide; Y is CR < 3 >, N or N-oxide; Z is CR < 4 >, N or N-oxide; At least one of W, X, Y, and Z is N or N-oxide; R9 and R10 are as defined. Methods of using such compounds in the treatment of various conditions, such as cancer, are also described. |