Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_399f43c51e40666f21a884409259b9e9 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-02 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5767 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-576 |
filingDate |
2016-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f218ce7e31352e63eeb2208583fd93c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5705c56b2cdd270e3e67c6d41a25b16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21223804056984bf599a9315e07fc1ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_670623831aef9c4c84513ab95faac797 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73adf8d9e7fde08f6f379c1ea005a959 |
publicationDate |
2018-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-20180045952-A |
titleOfInvention |
Method for screening treatment agent for enhancing immune activities against Hepatitis C virus |
abstract |
The present invention relates to a method for screening a substance that increases the formation of an IKK? / DDX3 complex in cells hyperphosphorylated with hepatitis C virus (HCV) NS5A (nonstructural protein 5A) protein, The NS5A protein interacts with the IKKε / DDX3 complex through the phosphorylated domain of IKKε, inhibits interferon-beta (IFN-β) and IRF3 phosphorylation induced by the IKKε / DDX3 complex, and inhibits DDX3-induced IKKε Type I interferon (Type I IFN) through the above-described screening method by confirming that it inhibits phosphorylation and IKK? / DDX3 interaction and inhibits NF-kB activity and p65 phosphorylation which are important for antiviral immune response , The inhibition of proliferation of hepatitis C virus and the congenital immune activity of cells infected with hepatitis C virus And to a method for screening a therapeutic substance for promoting immune activity. |
priorityDate |
2016-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |