| abstract |
The present invention relates to a CD55 target antibody and a antigen-binding fragment thereof, wherein the radioisotope is labeled with a monoclonal antibody having a high binding affinity for a decay-accelerating factor (CD55 or DAF) which is an immunosuppressive receptor, A cancer diagnostic kit comprising an isotope-labeled CD55 target antibody and information necessary for cancer diagnosis, a pharmaceutical composition for preventing or treating cancer comprising the radioactive isotope-labeled CD55 target antibody, and a radioactive isotope- And a CD55 target antibody for preventing or ameliorating cancer. The present invention relates to a CD55 target antibody and an antigen-binding fragment thereof, which are radioisotope labeled with a monoclonal antibody having a high binding affinity for a decay-accelerating factor (CD55 or DAF), and exhibit excellent binding affinity to CD55, And is highly useful for screening various cancer patients including lung cancer because of its high sensitivity and specificity. Furthermore, the antibody conjugated with the radioactive isotope compared to the monoclonal antibody has a higher effect of inhibiting cancer cell killing and cancer cell metastasis, and thus has a higher therapeutic effect in various cancer treatments including lung cancer. |