| abstract |
The present application relates to aryl-substituted dihydroquinolinones of formula (I), compositions comprising them and uses thereof in the treatment of diseases and conditions in which inhibition of the bromo-domain is indicated. For example, this application relates to aryl-substituted dihydroquinolinones as bromo-domain inhibitors and uses thereof. The present application also relates to the treatment or prevention of a neoplasm comprising a proliferative disorder, an autoimmune disorder, an inflammatory disorder, a skin disorder and a tumor and / or cancer. |