| abstract |
The present disclosure relates not only to MDM2 binding compounds but also to bifunctional compounds containing them, which are useful as regulators of targeted ubiquitination, in particular of various polyesters which are degraded and / or otherwise inhibited by the bifunctional compounds according to the invention Peptides and other proteins. Particularly, the present invention relates to a method for producing a target protein, which comprises ligating a MDM2 E3 ubiquitin ligase at one end thereof and a ligand binding to a target protein at the other end so that the target protein is arranged close to the ubiquitin ligase for the purpose of performing degradation (and inhibition) ≪ / RTI > Compounds that exhibit a broad range of pharmacological activity consistent with degradation / inhibition of almost all types of targeted polypeptides can be synthesized. |