http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180028007-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b0e688bf5dcaf406ff0e4eb7bf99ba05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_441f7c6829d19d1f693aa6ad677f2e8d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-82 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-10 |
| filingDate | 2017-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f86c6d6212ec3d33f385df133b9640e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df1ff044d8c4d7b559d42e2748265178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afc70a6cc996485cd014e54b9176f387 |
| publicationDate | 2018-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20180028007-A |
| titleOfInvention | Tumorigenic-specific enzyme sensitive-nanofiber coated gastrointestinal stent for eluting vorinostat and manufacturing method the same |
| abstract | The present invention relates to a stent of a borinostat-releasing gastrointestinal tract coated with a tumor-specific enzyme-responsive nanofiber and a method for producing the stent of the present invention. The stent of the present invention comprises a glycine-phenylalanine-leucine-glycine Gly-Phe-Leu-Gly, GFLG) peptides to synthesize a biodegradable polymer block copolymer; And dissolving the biodegradable polymer block copolymer and the vorinostat in an organic solvent to form a spinning solution and spinning the spinning solution into the stent body. As a result, nanofibers carrying a boronostat capable of inhibiting histone deacetylase can be prepared and coated on a stent for bile ducts, thereby providing a more effective use of bile ducts in the bile duct, which is one of the digestive organs in the human body. Can be obtained. In addition, the biodegradable polymer can be covalently bonded to another polymer as a peptide degraded by cathepsin B to produce a block copolymer, which can be used as a nanofiber bearing a boronostat and immobilized on a stent for dentistry. |
| priorityDate | 2016-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.