| abstract |
Non-human animal models for neurodegenerative and / or inflammatory diseases are provided, which include destruction at the C9ORF72 locus. In particular, the non-human animal described herein includes deletion of the entire coding sequence of the C9ORF72 locus. Prevention of autoimmune and / or inflammatory diseases (e.g., SLE, glomerulonephritis), one or more neurodegeneration (e.g., amyotrophic lateral sclerosis (ALS, also referred to as Lou Gehrig's disease) and frontotemporal dementia (FTD) A method of identifying a candidate for treatment that can be used to treat, delay, or treat is also provided. |