abstract |
(a) providing a library of candidate agents attached to a nucleic acid tag; (b) contacting the library with a solid support to attach the candidate agent to the solid support, thereby forming an array of candidate agents; (c) contacting the array with a screening agent, wherein at least one candidate agent in the array is reacted with the screening agent; (d) detecting the array to determine if at least one candidate agent in the array is reacting with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequence attached to the candidate agent in the array; And (f) identifying at least one candidate agent in the array responsive to the screening agent based on the tag sequence attached to the at least one candidate agent. |