| abstract |
The present invention provides a culture medium useful for the expression of an ADAMTS protein (e.g., ADAMTS13). Methods of expression and purification of ADAMTS proteins are also provided. In some embodiments, the media and methods of the present invention are useful for the expression of high specific activity ADAMTS proteins. Also provided is an ADAMTS, e. G., An ADAMTS13 protein composition, having a high specific activity, which is expressed and purified according to the methods provided herein. |