| abstract |
The present invention provides an anti-tampering pharmaceutical dosage form comprising a plurality of particles comprising a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; The pharmacologically active compound is dispersed in the matrix comprising the polyalkylene oxide and the disintegrant; The content of said disintegrant is greater than 5.0 wt.%, Based on the total weight of said pharmaceutical dosage form and / or on a basis of the total weight of said particles; The content of said polyalkylene oxide is at least 25 wt.%, Based on the total weight of said pharmaceutical dosage form and / or based on the total weight of said particles; Wherein said dosage form provides immediate release of said pharmacologically active compound according to European Pharmacopoeia (Ph. Eur.) Under in vitro conditions. |