http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20170134905-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3f4111205626392f051303e7b8819 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-8813 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-8831 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-8818 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-7233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 |
| filingDate | 2016-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcd944c1dfc8d038344a51ae0bedfeed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bef4f36fcc09b0611539ffc998c7f69b |
| publicationDate | 2017-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20170134905-A |
| titleOfInvention | Simultaneous analysis method for neurotransmitters including three or more |
| abstract | The present invention relates to a method for simultaneous quantitative analysis of neurotransmitters in brain tissue. Dopamine, serotonin, and GABA Prepare brain tissues containing three or more neurotransmitters and pretreatment to simplify pretreatment without conventional solid-phase extraction and derivatization methods, concentration without additional solvents Pretreatment is possible with only one solvent. The method of the present invention can accurately quantify the neurotransmitter without being influenced by the measurement error caused by the fluctuation caused by the UPLC-MS analysis step by adding the isotope labeled standard as an internal standard substance, thereby improving the reliability of the assay method . As a stationary phase, it is possible to separate and quantify the neurotransmitter dopamine, serotonin and three kinds of GABA by using a nonpolar column without overlapping the nonpolar column and the polar column. By injecting a polar substance into the nonpolar column, And the analysis time can be shortened to 3 minutes or less. In addition, since the present invention has the same mobile phase composition as dopamine, serotonin and GABA, it is possible to perform quantitative analysis with only a single injection volume in the isocratic elution condition, so that even a small number of samples can be quantitatively analyzed at the same time. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108459095-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210150672-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107843673-A |
| priorityDate | 2016-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.