| abstract |
It is an object of the present invention to provide an antithrombogenic metal material exhibiting high safety against low hemolytic toxicity and continuously exhibiting high antithrombogenicity. The present invention relates to a polymer comprising a phosphonic acid derivative or a catechol derivative and a compound selected from the group consisting of alkyleneimine, vinylamine, allylamine, lysine, protamine and diallyldimethylammonium chloride as constituent monomers, Wherein the polymer is covalently bonded to the phosphonic acid derivative or the catechol derivative, and the phosphonic acid derivative or the catechol derivative is covalently bonded to the phosphonic acid derivative or the catechol derivative, Is bonded to the metal material through its phosphonic acid group or catechol group and the ratio of the amount of nitrogen atom present relative to the amount of total atoms present on the surface as measured by X-ray photoelectron spectroscopy (XPS) is from 4.0 to 13.0 The present invention provides an anti-thrombogenic metal material which is in terms of atomic%. |