abstract |
The present invention relates to a novel compound, and a method for producing an inhibitor of deubiquitinating enzyme (DUB). In particular, the present invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 (USP 30). The invention also relates to the use of a DUB inhibitor in the treatment of symptoms and cancer accompanying mitochondrial dysfunction. The compounds of the present invention include compounds having the formula (II): < EMI ID = In this formula, Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 8 , R 9 , R 10 , R 12 , Z, Y and m are as defined herein. |