| abstract |
The present invention discloses 2-aminopyrimidine compounds and their pharmaceutical compositions and applications, wherein the structure of the 2-aminopyrimidine compound is as shown in I, wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, Z, W, and (i) are as defined in the specification and claims. These compounds can effectively inhibit the growth of various tumor cells, The antitumor drug can be produced, and it is possible to overcome the chemical resistance caused by the conventional drugs phytinib, elotinib and the like, and it is possible to overcome the toxicity of the antitumor drug in tumors, especially wild type non-small cell lung cancer And has good pharmacokinetic properties. (I) (i) |