| abstract |
The present invention relates to a novel bifunctional CTI-F 1 -L 1 -TL 2 -F 2 family of F 1 , L 1 , T, L 2 and F 2 as defined herein, useful for the treatment of a proliferative disease. CTI and CBI-CTI dimers wherein the dimer of the invention functions as a linker-payload compound useful in connection with the manufacture or administration of an independent drug, an antibody-drug-conjugate (ADC) Lt; / RTI > And methods of treating pathological conditions involving cancer using compositions comprising said dimer, linker-payload and ADC, and dimers, linker-payloads, and ADCs. |