| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b90478d5d2ff2012c0bc65338bcaab4e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb258be6a48fd6826b8c923ea4234dff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18e454dd046bbff3462019be55956ee7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3521
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-346
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3231 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-712
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-712 |
| filingDate |
2006-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e66a695c215c101fb0f4d48b83dbb144
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9337b230cf90ecbe736f3506ad3d6c77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b621e4008b92f56ee69d83eeafebafde |
| publicationDate |
2017-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20170119730-A |
| titleOfInvention |
Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease |
| abstract |
Disclosed are methods and compositions for controlling the expression of these receptors using compounds that modulate splicing of pre-mRNAs encoding TNF receptors (TNFR1 and TNFR2) and other receptors belonging to the TNFR superfamily. In particular, these compounds produce a soluble form of the receptor that acts as an antagonist which causes the elimination of the transmembrane domain of the receptor and reduces the activity of TNF-a activity or related ligands. Reducing TNF-a activity provides a method of treating and ameliorating an inflammatory disease or condition associated with TNF-a activity. Likewise, diseases associated with other ligands can be treated in a similar manner. In particular, the compound of the present invention is a splice-splicing switching oligomer (SSO) which is a small molecule stable in vivo, is hybridized to RNA in a sequence-specific manner, and is not degraded by an antigen H . |
| priorityDate |
2005-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |