http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20170117479-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a02c40617d712e62677fd6b4ff2db54b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-12 |
| filingDate | 2016-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_950ad08b5f567f3ba2d8a75005828ebc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_365f5e187fd2d8d0858b5e12cc97281d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33f49c7be740eb038a907d07c2d78b91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_251e62ae49ff8387e67332a53047c4a8 |
| publicationDate | 2017-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20170117479-A |
| titleOfInvention | Substituted mono- and polyazanaphthalene derivatives and uses thereof |
| abstract | A compound of Formula I (in formula I, A is CH or N; B is CR or N; D is CR a; R is H, OH or represents an NH 2; R1 and R2 are each independently hydrogen, N (R 3) 2 , halogen, cyano, nitro, R 4 -C 1 -C 4 alkyl, R 4 -C 1 -C 4 halogenoalkyl, OH, R 4 -C 1 -C 4 alkoxy, R 4 -C 1 -C 4 halogenoalkoxy, C1-C4 alkoxy, C1-C4 alkoxy, C1-C4 alkoxy, R4-C1-C4 halogenoalkylthio, R3 is independently at each occurrence hydrogen, R4- when the independently represent hydrogen or C1-C4 alkyl; R4 is hydrogen, independently for each occurrence, halogen, cyano, OH, SH, NH 2, NH (CH 3) or N (CH 3) represents two; X represents a group of the formula -E- or -EF-, wherein E and F are different and are selected from the group consisting of -C (R3a) 2- , - (C = O) -, -NR3a- and -O- And F is connected to Y, provided that when X represents -EF-, then E Is one of F is -C (R3a) 2 - or - (C = O) - denotes a; Y is C1-C6 alkyl, mono-or (in which can be unsaturation) bicyclic C3-C11 cycloalkyl, Mono- or bicyclic 3- to 11-membered heterocycloalkyl (which may be partially unsaturated), a mono- or bicyclic group comprising at least one aryl or heteroaryl cycle, wherein the hetero A cycloalkyl group and a group comprising said at least one heteroaryl cycle contain one or more heteroatoms selected from nitrogen, oxygen and sulfur, said group Y being unsubstituted or substituted by one or more substituents, , One or more than one nitrogen atom having a lone electron pair; Z comprises at least one aryl or heteroaryl cycle, No-or bicyclic represents a group, being the heteroaryl cycle is substituted by a said aryl or heteroaryl group is unsubstituted or substituted one or more substituents comprising at least one heteroatom selected from nitrogen, oxygen and sulfur); A tautomer of said compound, a mixture of two tautomeric forms of said compound, and a pharmaceutically acceptable salt of said compound, a tautomer thereof, or a mixture of two tautomeric forms thereof, X is - (C = O) - or - (C = O) -NR3a- to represent (wherein, R3a represents a hydrogen or a C1-C4 alkyl), Y comprises at least one primary amino group -NH 2 and; Disclosed are compounds of formula I useful for the treatment of proliferative disorders or diseases, such as cancer. (I) |
| priorityDate | 2015-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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