| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_832231e56616a3e87c01de72bb8aaeba |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-572
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2017-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2835120b5a0f6d5411fe37156b0d2fc4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_804c21c2fcc4cf5f6cec26dbbb88dd30 |
| publicationDate |
2017-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20170113246-A |
| titleOfInvention |
Composition for Inhibiting Tolerance Against Epidermal Growth Factor Receptor Targeting Inhibitor |
| abstract |
The present invention relates to methods for modulating resistance or susceptibility to an EGFR (EGFR) targeting agent through a peptide that specifically binds Neuropilin 1. In addition, the ability of the fusion antibody to specifically bind to neurofilin 1 to be fused to the EGFR target antibody and the resistance or susceptibility to the EGFR targeting agent by the combined administration of the EGFR targeting agent and the antibody heavy chain constant region fused with the peptide ≪ / RTI > In addition, a fusion antibody in which a peptide specifically binding to neurofilin 1 according to the present invention is fused to an EGFR target antibody overcomes the resistance to EGFR target antibody in pancreatic cancer. In addition, a fusion antibody in which a peptide specifically binding to neurofilin 1 is fused to an EGFR target antibody overcomes the resistance to an EGFR target antibody in a lung cancer that is resistant to the EGFR target antibody. Therefore, through the peptide specifically binding to neurofilin 1 according to the present invention, high efficacy can be expected in the treatment of various tumors having resistance to an EGFR target preparation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11235018-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019088348-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190134448-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101975599-B1 |
| priorityDate |
2016-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |