| abstract |
Disclosed are polypeptides and agents that specifically bind to TNF receptor superfamily proteins, particularly those that specifically bind to GITR, OX40 or CD40. The polypeptide or agent may comprise a fusion polypeptide, in particular a polypeptide comprising GITRL, OX40L, or CD40L and / or a bispecific agent. Methods of treating diseases such as cancer as well as methods of using polypeptides or agents to induce and / or enhance an immune response are also disclosed. |