Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_83dffc287358331deccd774ddf93f551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c673fa38a73479f2a41425a22f3832f |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y118-01002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0071 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 |
filingDate |
2016-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86ec1529f04518877d416bffd809f4d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9f400fbb6c8f124d6c69bcf78a9d1d0 |
publicationDate |
2017-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-20170103405-A |
titleOfInvention |
Codon optimized cyclosporine specific P450 hydroxylase and whole cell biotransformation of cyclosporine in E. coli using thereof |
abstract |
The present invention relates to a codon-optimized cyclosporine (CsA) -specific P450 hydroxylase and an E. coli-based optimized cyclosporin biotransformation method using the same, and the present invention relates to a codon-optimized cyclosporin- Lt; RTI ID = 0.0 > hydroxylase < / RTI > The present invention also relates to a recombinant vector comprising the codon-optimized hydroxylase gene; And a ferredoxin (ferredoxin) gene and the ferredoxin -NADP + reductase (ferredoxin-NADP + reductase) provides a recombinant microorganism transformed with a recombinant expression vector containing the gene. Using this recombinant microorganism, a pre-cell bioswitching system capable of producing CsA-4-OH in a cost-effective manner has been developed, and the system is expected to be effectively applied to the subsequent scale-up production of hair growth promoters. |
priorityDate |
2016-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |