| abstract |
Discloses methods and compositions for delivering a target tissue, such as an eye, into a bioactive form while protecting said antioxidant from degradation of lutein or other antioxidants. The antioxidant is captured in a protein, such as a nanoparticle containing a proposal or a polymer, such as poly (lacto-co-glycolic acid) (PLGA). Surfactants are preferably associated with nanoparticles as well, which further helps protect the antioxidants. After administration of the nanoparticles to the target tissue, the bioactive antioxidant is released into the tissue over time. Optionally, in order to promote delayed release of the antioxidant, the nanoparticles are preferably mixed with a heat-sensitive, bioadhesive gel. Such methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts. |