| abstract |
The invention relates to a derivative of a FGF21 protein having a cysteine residue at a position corresponding to positions 167, 169, 170, 171, 172, 173, 174, 175 of mature human FGF21 at positions 180 or 181 and a side chain attached to the cysteine The branch is about its derivatives. The FGF21 derivatives of the invention exhibit a high degree of potency towards FGF receptors. The invention also relates to pharmaceutical compositions comprising such FGF21 derivatives and pharmaceutically acceptable excipients, as well as the medical uses of FGF21 derivatives. |