| abstract |
The present invention relates to: (i) 6-membered heteroaryl substituted fatty acid cystamine conjugates, compositions therefor, autophoresis such as cystic fibrosis, idiopathic pulmonary fibrosis (IPF), neurodegenerative diseases, inflammation (Ii) a method for treating the following diseases: idiopathic pulmonary fibrosis, mitochondrial diseases, Ray's syndrome, diabetes mellitus, and hearing loss (DAD), Levers congenital optic neuropathy, neuropathy-ataxia-retinitis and ptosis (NARP), muscle-resistant gastrointestinal encephalopathy (MNG1E), liver metastatic spasmodic epilepsy with atypical red fibers (MERRF), and mitochondrial myopathy- (4Z, 7Z, 10Z, 13Z, 16Z, 19Z) -N- (2-mercaptoethyl) docosa-4,7,10 , 13,16,19-hexenamide or (5Z, 8Z , 11Z, 14Z, 17Z) -N- (2-mercaptoethyl) icosa-5,8,11,14,17-pentaenamide. |